Small Business Innovation Research (SBIR) Small Business Technology Transfer (STTR)


NIH’s SBIR and STTR programs are an integral source of capital for early stage U.S. small businesses that are creating innovative technologies to improve health. These competitive programs help small businesses break into the federal research and development (R&D) arena, create life-saving technologies, and stimulate economic growth.

What is SBIR and STTR?

The SBIR and STTR programs are congressionally-mandated set-aside programs for U.S. small businesses to engage in R&D that has a strong potential for commercialization.

Read More

Grants vs. Contracts

The NIH SBIR program supports research using both grants and contracts. 

Read More

Three-Phase Program

Both the SBIR and STTR programs are divided into three phases. NIH has special technical assistance and gap-funding programs to help small businesses move their technologies from the lab to the market.

Read More

SBIR and STTR Critical Differences

The SBIR and STTR programs have similar objectives, but differ in two major ways related to the principal investigator (PI) and non-profit research partner.

Read More

Small Business Eligibility Criteria

Only U.S. small business concerns are eligible to submit applications SBIR and STTR solicitations.

Read More

NIH Institutes and Centers with SBIR/STTR

NIH is comprised of 27 Institutes and Centers (ICs), each with a specific research agenda, often focusing on particular diseases or body systems. Of these 27 ICs, 24 have SBIR and STTR programs.

Women-Owned and Socially and Economically Disadvantaged Small Businesses

The SBIR and STTR programs encourage the participation of women-owned (WOSB) and socially and economically disadvantaged (SDB) small businesses.

Read More

Contact Us

The NIH SBIR/STTR Program Office is here to serve you! Whether you are an experienced entrepreneur with a long track record of success, or a fledgling small business that is just getting started, we welcome any questions you may have regarding any aspect of our programs.

Read More