Special Announcements for Small Business Research Opportunities

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The SBIR/STTR Program

Targeted SBIR/STTR Funding Announcements

Receipt dates for the following Program Announcements (PAs) and Request for Applications (RFAs) may vary. See the NIH Guide for Grants and Contracts for all NIH RFA and PA announcements.

SBIR and STTR Omnibus Solicitations (Parent Announcements)

SBIR Omnibus/Parent Clinical Trial Not Allowed Funding Opportunity Announcement (PA-20-260)

STTR Omnibus/Parent Clinical Trial Not Allowed Funding Opportunity Announcement (PA-20-265)

SBIR Omnibus/Parent Clinical Trial Required Funding Opportunity Announcement (PA-20-262)

STTR Omnibus/Parent Clinical Trial Required Funding Opportunity Announcement (PA-20-261)

Deadlines: September 8, 2020; January 5, 2021; April 5, 2021

Announcement Number	Issuing Organization	Other Participating Organizations	Release Date	Opening Date (SF424 Only)	Receipt Date(s)	Expiration Date	Activity Code(s)	Title
PAR-21-267	NINDS		07/16/2021	30 days prior to the application due date	Standard dates apply The first standard due date for this FOA is September 7, 2021.	04/06/2024	R41/R42	NINDS Exploratory Clinical Trials for Small Business (R41/R42 Clinical Trial Required)
PAR-21-266	NINDS		07/15/2021	30 days prior to the application due date	Standard dates apply The first standard due date for this FOA is September 7, 2021.	04/06/2024	R43/R44	NINDS Exploratory Clinical Trials for Small Business (R43/R44 Clinical Trial Required)
PAR-21-265	NINDS		07/15/2021	3?0 days prior to the application due date	Standard dates apply The first standard due date for this FOA is September 7, 2021.	04/06/2024	R44	NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Clinical Trials and Clinical Research (R44 Clinical Trial Optional)
PAR-21-247	NHGRI	NIAID, NCI	07/12/2021	30 days prior to the application due date	October 1, 2021; June 15, 2022; June 15, 2023 All applications are due by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on the listed date(s). Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	06/16/2023	R43/R44	Technology Development for Single-Molecule Protein Sequencing (R43/R44 Clinical Trial not allowed)
PA-21-259	NIH	NCI, NIAMS, NCATS, NIDCD, NIAAA, NIEHS, NIAID, NIDDK, NINR, NHLBI, NHGRI, NEI, NIBIB, NLM, NIMHD, NCCIH, NIMH, NIA, NIDCR, NINDS, NICHD, NIDA, NIGMS, ORIP	07/08/2021	Not Applicable	Standard dates apply	04/06/2022	R43/R44	PHS 2021-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)
PA-21-262	NIH	NCI, NIAMS, NHGRI, NIDCD, NIAID, NIAAA, NIEHS, NIDDK, NINR, NCATS, NHLBI, NEI, NIMHD, NCCIH, NIBIB, NIA, NIMH, NIDCR, NLM, NICHD, NIDA, NINDS, NIGMS, ORIP	07/08/2021	Not Applicable	Standard dates apply	04/06/2022	R41/R42	PHS 2021-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)
PA-21-261	NIH	NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIBIB, NICHD, NIDA, NIDCD, NIEHS, NIGMS, NIMH, NIMHD, NINR	07/08/2021	Not Applicable	Standard dates apply	04/06/2022	R41/R42	PHS 2021-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)
PA-21-260	NIH	NIDCD, NIAAA, NIEHS, NIDDK, NINR, NCI, NHLBI, NHGRI, NEI, NIMHD, NCCIH, NIBIB, NIA, NIMH, NICHD, NIDA, NIGMS	07/08/2021	Not Applicable	Standard dates apply	04/06/2022	R43/R44	PHS 2021-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)
RFA-DK-21-021	NIDDK	NIAID	06/25/2021	January 17, 2022 and September 07, 2022	February 17, 2022 and October 7, 2022	10/08/2022	R43/R44	Support for Small Business Innovation Research (SBIR) to Develop New Methods and Technologies for Assessment of Risk and for Early Diagnosis and Prognosis of Type 1 Diabetes (R43/R44 Clinical Trial Not Allowed)
RFA-AG-22-007	NIA		06/10/2021	September 26, 2021	October 26, 2021	10/27/2021	R43/R44	NIA Research and Entrepreneurial Development Immersion (REDI): Entrepreneurial Small Business Transition Award (R43/R44 Clinical Trial Optional)
RFA-AG-22-014	NIA		06/10/2021	September 26, 2021	October 26, 2021	10/27/2021	R41/R42	NIA Research and Entrepreneurial Development Immersion (REDI): Entrepreneurial Small Business Transition Award (R41/R42 Clinical Trial Optional)
RFA-DK-21-012	NIDDK		05/19/2021	February 09, 2022 and September 7, 2022	March 9, 2022 and October 7, 2022	10/08/2022	R43/R44	Support for Small Business Innovation Research (SBIR) to Development and Testing of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (R43/R44 Clinical Trial Not Allowed)
RFA-ES-21-005	NIEHS		05/11/2021	June 30, 2021	July 30, 2021	07/31/2021	R43/R44	SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed)
RFA-DK-21-011	NIDDK		05/06/2021	February 9, 2022 and September 7, 2022	March 9, 2022 and October 7, 2022	10/08/2022	R43/R44	Support for Small Business Innovation Research (SBIR) to Develop New Technologies for Development and Integration of Novel Components for Open and Closed Loop Hormone Replacement Platforms for T1D Therapy (R43/R44 Clinical Trial Not Allowed)
PAR-21-224	NINDS		05/05/2021	Not Applicable	Standard dates apply *** Note new SBIR/STTR Standard Due Dates.	04/06/2024	U44	NeuroNEXT Small Business Innovation in Clinical Trials (U44 Clinical Trial Optional)
PAR-21-225	ORIP		04/30/2021	Not Applicable	Standard dates apply The first standard due date for this FOA isSeptember 6, 2021	09/06/2024	R43/R44	Novel Tools and Devices for Animal Research Facilities and to Support Care of Animal Models (R43/R44 Clinical Trial Not Allowed)
PAR-21-226	ORIP		04/30/2021	Not Applicable	Standard dates apply The first standard due date for this FOA is September 5, 2021	09/06/2024	R41/R42	Novel Tools and Devices for Animal Research Facilities and to Support Care of Animal Models (R41/R42 Clinical Trial Not Allowed)
RFA-NS-21-022	NINDS		04/28/2021	60 days prior to the receipt date.	July 1, 2021; October 20, 2021; February 18, 2022; June 20, 2022; October 18, 2022; February 21, 2023; June 19, 2023; October 18, 2023; February 20, 2024	02/21/2024	U44	Translational Neural Devices (U44 Clinical Trial Optional)
RFA-DA-22-001	NIDA		04/27/2021	July 13, 2021	August 13, 2021	08/14/2021	R43/R44	Mobile Health Solutions to rectify digital inequality in communities affected by drug addiction (R43/R44 Clinical Trial Optional)
PAR-21-233	NINDS	NIAAA, NIA, NCCIH, NICHD, NIBIB, NIMH, OBSSR, NIDCR, NIDA, NEI	04/23/2021	30 days prior to the application due date	August 10, 2021, February 9, 2022, August 9, 2022, February 9, 2023, August 9, 2023, February 9, 2024	04/06/2024	U44	Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)
RFA-HD-22-018	NICHD		04/15/2021	30 days prior to application due date	July 29, 2021	07/30/2021	R43	Biomarker Research to Support Fertility Regulation Development by Small Business (R43 Clinical Trial Optional)
RFA-DA-22-019	NIDA		04/08/2021	Not Applicable	August 10, 2021 No late applications will be accepted for this Funding Opportunity Announcement.	08/11/2021	R43/R44	Leveraging Artificial Intelligence (AI) tools for Substance Use Disorders (SUD) drug discovery and development (R43/R44 - Clinical Trial Not Allowed)
RFA-DA-22-021	NIDA		04/08/2021	Not Applicable	August 10, 2021 No late applications will be accepted for this Funding Opportunity Announcement.	08/11/2021	R41/R42	Leveraging Artificial Intelligence (AI) tools for Substance Use Disorders (SUD) drug discovery and development (R41/R42 - Clinical Trial Not Allowed)
RFA-HD-22-010	NICHD		03/31/2021	30 days prior to the application due date	July 29, 2021	07/30/2021	R43/R44	Technologies to Advance Precision Medicine for Reproductive Health and Infertility (R43, R44 Clinical Trial Optional)
RFA-HG-21-008	NHGRI		03/30/2021	30 days prior to the application due date	June 25, 2021; March 1, 2022; February 1, 2023 All applications are due by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on the listed date(s). Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	02/02/2023	R43/R44	Transformative Nucleic Acid Sequencing Technology Innovation and Early Development (R43/R44)
RFA-HD-22-019	NICHD		03/29/2021	30 days prior to application receipt date	July 29, 2021	07/30/2021	R43	User-Based Design to Aid in Contraceptive Development by Small Business (R43 Clinical Trial Not Allowed)
RFA-CA-21-036	NCI		03/25/2021	July 6, 2021	August 6, 2021	08/07/2021	R44	SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional)
PAR-21-114	NINDS		01/25/2021	30 days prior to the application due date	Standard dates apply The first standard due date for this FOA is April 5, 2021	01/06/2024	R44	NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Pre-Clinical Research (R44 Clinical Trial Not Allowed)
PAR-21-082	NIAID		01/14/2021	30 days prior to the application due date	May 14, 2021; September 13, 2021; January 14, 2022; May 13, 2022; September 13, 2022; January 13, 2023; May 13, 2023; September 14, 2023; January 13, 2024	01/14/2024	U44	NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required)
RFA-TR-21-010	NCATS		01/13/2021	March 13, 2021	April 13, 2021, September 13, 2021, January 12, 2022	01/13/2022	U44	Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required)
PAR-21-059	NINDS		11/19/2020	30 days prior to the application due date.	March 15, 2021, June 22, 2021, February 22, 2022, June 22, 2022, February 22, 2023, and June 22, 2023	09/08/2023	U44	Clinical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional)
PAR-21-057	NINDS		11/19/2020	30 days prior to the application due date.	February 22, 2021, June 22, 2021, February 22, 2022 June 22, 2022, February 22, 2023, June 22, 2023	09/08/2023	U44	Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional)
RFA-MH-21-112	NIMH		11/13/2020	30 days prior to the application due date	?February 18, 2021; October 15, 2021, June 15, 2022	06/16/2022	R43/R44	Service-Ready Tools for Identification, Prevention, and Treatment of Individuals at Risk for Suicide (R43/R44 Clinical Trial Optional)
PAR-21-030	NIAMS		10/08/2020	December 5, 2020	Standard datesapply The first standard due date for this FOA is January 5, 2021.	09/06/2022	R43/R44	Late-Stage Translation of Biomedical and Behavioral Research Results in Arthritis and Musculoskeletal and Skin Diseases from Academic/Non-profit Lab to Marketplace (SBIR [R43/R44] Clinical Trial Not Allowed)
PAR-20-239	NIGMS		06/25/2020	Not Applicable	September 4, 2020; September 3, 2021; September 2, 2022	09/03/2022	R41/R42	Interactive Digital Media STEM Resources for Pre-College and Informal Science Education Audiences (STTR) (R41/R42 Clinical Trial Not Allowed)
PAR-20-244	NIGMS		06/25/2020	Not Applicable	September 4, 2020; September 3, 2021; September 2 , 2022	09/03/2022	R43/R44	Interactive Digital Media STEM Resources for Pre-College and Informal Science Education Audiences (SBIR) (R43/R44 Clinical Trial Not Allowed)
RFA-HG-20-016	NHGRI	NCATS	03/19/2020	30 days prior to the application due date	June 24, 2020; March 9, 2021; February 4, 2022 All applications are due by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on the listed date(s). Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	02/05/2022	R43/R44	Novel Synthetic Nucleic Acid Technology Development (R43/R44)( Clinical Trial not allowed)
PAR-20-111	NINDS	NCCIH, NIDCR, NIAAA, NICHD, NIDA, NIA, NEI, OBSSR, NIMH	03/03/2020	30 days prior to the application due date	August 11, 2020, February 9, 2021,August 10, 2021,February 9, 2022,August 9, 2022, February 9, 2023 by 5:00 PM local time of applicant organization.	05/08/2023	U44	Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)
PAR-20-109	NCATS	NINDS, NIA, NIGMS, NIAID	02/06/2020	30 days prior to the application due date	Standard dates apply The first standard due date for this FOA is April 5, 2020	01/06/2022	R41/R42	Non-Viral Technologies for in vivo Delivery of Genome Editors (R41/R42 Clinical Trial Not Allowed)
PAR-20-098	NCATS	NIA, NIGMS, NIAID, NINDS	02/06/2020	30 days prior to the application due date	Standard dates apply The first standard due date for this FOA is April 5, 2020	01/06/2022	R43/R44	Non-Viral Technologies for in vivo Delivery of Genome Editors (R43/R44 Clinical Trial Not Allowed)
PA-20-025	NIMH	NIEHS, NIGMS, NCATS, NIDCR, NIDA, NEI, NHGRI	01/07/2020	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization.	01/06/2023	R41/R42	Development of Highly Innovative Tools and Technology for Analysis of Single Cells (STTR) (R41/R42 Clinical Trial Not Allowed)
PA-20-047	NIMH	NCATS, NCI, NEI, NHGRI, NIDA, NIDCR, NIEHS, NIGMS	01/07/2020	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization.	01/06/2023	R43/R44	Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44 Clinical Trial Not Allowed)
RFA-NS-20-009	NINDS	NICHD, NIBIB, NIMH, NIDDK, NIAAA, NCCIH, ORIP, NIA, NIAMS, NHLBI, NIGMS, NCI, NIMHD, NCATS, NEI, NINR, NIDCR, NLM	10/04/2019	30 days prior to the application due date	January 8, 2020, April 7, 2020, September 9, 2020, January 6, 2021, April 6, 2021, September 8, 2021, January 6, 2022, April 6, 2022, and September 8, 2022	09/09/2022	R41/R42	HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed)
RFA-NS-20-008	NINDS	NCCIH, NCI, NEI, NHLBI, NIA, NIAAA, NIAMS, NIBIB, NICHD, NIDDK, NIGMS, NIMH, NIMHD, NINR	10/04/2019	30 days prior to the application due date	January 8, 2020, April 7, 2020, September 9, 2020, January 6, 2021, April 6, 2021, September 8, 2021, January 6, 2022, April 6, 2022, and September 8, 2022	09/09/2022	R41/R42	HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Required)
RFA-NS-20-010	NINDS	NCCIH, NCI, NEI, NHLBI, NIA, NIAAA, NIAMS, NIBIB, NICHD, NIDDK, NIGMS, NIMH, NIMHD, NINR	10/04/2019	30 days prior to the application due date	January 8, 2020, April 7, 2020, September 9, 2020, January 6, 2021, April 6, 2021, September 8, 2021, January 6, 2022, April 6, 2022, and September 8, 2022	09/09/2022	R43/R44	HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 - Clinical Trial Required)
RFA-NS-20-011	NINDS	NIAAA, NIA, NIAMS, NCCIH, NCI, NIDDK, NIGMS, NICHD, NIBIB, NIMHD, NLM, NIMH, NINR, NCATS, ORIP, NHLBI, NIDCR, NEI	10/04/2019	30 days prior to the application due date	January 8, 2020, April 7, 2020, September 9, 2020, January 6, 2021, April 6, 2021, September 8, 2021, January 6, 2022, April 6, 2022, and September 8, 2022	09/09/2022	R43/R44	HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 - Clinical Trial Not Allowed)
PAS-19-316	NIA	NINDS	07/18/2019	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity are due on these dates. The first standard application due date for this FOA is September 5, 2019.	09/07/2022	R43/R44	Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R43/R44 Clinical Trial Optional)
PAS-19-317	NIA	NINDS	07/18/2019	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity are due on these dates. The first standard application due date for this FOA is September 5, 2019.	09/07/2022	R41/R42	Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R41/R42 Clinical Trial Optional)
RFA-DA-19-020	NIDA	NCATS	12/10/2018	30 days prior to the application due date	January 8, 2019, April 9, 2019, September 8, 2019, April 9, 2020, September 8, 2020, April 9, 2021, September 8, 2021, by 5:00 PM local time of applicant organization. No late applications will be accepted. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	09/09/2021	R41/R42	HEAL Initiative: Americas Startups and Small Businesses Build Technologies to Stop the Opioid Epidemic (R41/R42 - Clinical Trial Optional)
RFA-DA-19-019	NIDA	NCATS	12/10/2018	30 days prior to application due date	January 8, 2019, April 9, 2019, September 8, 2019, April 9, 2020, September 8, 2020, April 9, 2021, September 8, 2021, by 5:00 PM local time of applicant organization. No late applications will be accepted. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	09/09/2021	R43/R44	HEAL Initiative: Americas Startups and Small Businesses Build Technologies to Stop the Opioid Epidemic (R43/R44 - Clinical Trial Optional)
PA-19-076	NIDCR		11/26/2018	Not Applicable	Standard dates apply	01/06/2022	R43/R44	Enabling Technologies to Accelerate Development of Oral Biodevices (R43/R44 Clinical Trial Not Allowed)
PA-19-075	NIDCR		11/26/2018	Not Applicable	Standard dates apply	01/06/2022	R41/R42	Enabling Technologies to Accelerate Development of Oral Biodevices (R41/R42 Clinical Trial Not Allowed)
PAR-19-061	NHGRI		11/08/2018	30 days prior to the application due date	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	09/06/2021	R43/R44	Investigator Initiated Research in Computational Genomics and Data Science (R43/R44 Clinical Trial Not Allowed)
PA-19-043	NHGRI		10/31/2018	30 days prior to the application due date	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	09/06/2021	R43/R44	Novel Approaches for Relating Genetic Variation to Function and Disease (R43/R44 Clinical Trial Not Allowed)
PA-19-033	NIDCR	NCATS, NCI, NHLBI, NIMH, NLM	10/24/2018	Not Applicable	Standard dates apply by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.	09/06/2021	R41/R42	Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project (IDG) (R41/R42 Clinical Trial Not Allowed)
PA-19-034	NIDCR	NCATS, NCI, NHLBI, NIMH, NLM	10/24/2018	Not Applicable	Standard dates apply by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.	09/06/2021	R43/R44	Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project (IDG) (R43/R44 Clinical Trial Not Allowed)
PA-19-022	NIDCR		10/09/2018	Not Applicable	Standard dates apply	09/06/2021	R43/R44	Advancing Imaging, Device Production, and Clinical Capabilities in Digital Dentistry (R43/R44 Clinical Trial Not Allowed)
PA-19-021	NIDCR		10/09/2018	Not Applicable	Standard dates apply	09/06/2021	R41/R42	Advancing Imaging, Device Production, and Clinical Capabilities in Digital Dentistry (R41/R42 Clinical Trial Not Allowed)
PA-18-927	NIMH		09/19/2018	Not Applicable	Standard dates apply , by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.	09/06/2021	R41/R42	Innovative Technologies for HIV Behavioral and Social Science Research (R41/R42 Clinical Trial Optional)
PA-18-928	NIMH		09/19/2018	Not Applicable	Standard dates apply , by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.	09/06/2021	R43/R44	Innovative Technologies for HIV Behavioral and Social Science Research (R43/R44 Clinical Trial Optional)
PA-18-709	NIMH		03/15/2018	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization.	09/06/2021	R41/R42	Novel Tools for Investigating Brain-derived GPCRs in Mental Health Research (R41/R42)-Clinical Trial Not Allowed
PA-18-708	NIMH		03/15/2018	30 days prior to the application due date	Standard dates apply , by 5:00 PM local time of applicant organization.	09/06/2021	R43/R44	Novel Tools for Investigating Brain-derived GPCRs in Mental Health Research (R43/R44 Clinical Trial Not Allowed)
PA-18-705	NINDS	NCI, NEI, NIA, NIAAA, NIDA, NIDCR, NINR	03/06/2018	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	09/06/2021	R43/R44	SBIR Technology Transfer (R43/R44 Clinical Trial Not Allowed)

Announcement
Number

Issuing
Organization

Other
Participating
Organizations

Release
Date

Opening Date
(SF424 Only)

Receipt
Date(s)

Expiration
Date

Activity
Code(s)

Title

PAR-21-267

NINDS

07/16/2021

30 days prior to the application due date

Standard dates apply The first standard due date for this FOA is September 7, 2021.

04/06/2024

R41/R42

NINDS Exploratory Clinical Trials for Small Business (R41/R42 Clinical Trial Required)

PAR-21-266

NINDS

07/15/2021

30 days prior to the application due date

Standard dates apply The first standard due date for this FOA is September 7, 2021.

04/06/2024

R43/R44

NINDS Exploratory Clinical Trials for Small Business (R43/R44 Clinical Trial Required)

PAR-21-265

NINDS

07/15/2021

3?0 days prior to the application due date

Standard dates apply The first standard due date for this FOA is September 7, 2021.

04/06/2024

R44

NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Clinical Trials and Clinical Research (R44 Clinical Trial Optional)

PAR-21-247

NHGRI

NIAID, NCI

07/12/2021

30 days prior to the application due date

October 1, 2021; June 15, 2022; June 15, 2023 All applications are due by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on the listed date(s). Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

06/16/2023

R43/R44

Technology Development for Single-Molecule Protein Sequencing (R43/R44 Clinical Trial not allowed)

PA-21-259

NIH

NCI, NIAMS, NCATS, NIDCD, NIAAA, NIEHS, NIAID, NIDDK, NINR, NHLBI, NHGRI, NEI, NIBIB, NLM, NIMHD, NCCIH, NIMH, NIA, NIDCR, NINDS, NICHD, NIDA, NIGMS, ORIP

07/08/2021

Not Applicable

Standard dates apply

04/06/2022

R43/R44

PHS 2021-2 Omnibus Solicitation of the NIH, CDC and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Not Allowed)

PA-21-262

NIH

NCI, NIAMS, NHGRI, NIDCD, NIAID, NIAAA, NIEHS, NIDDK, NINR, NCATS, NHLBI, NEI, NIMHD, NCCIH, NIBIB, NIA, NIMH, NIDCR, NLM, NICHD, NIDA, NINDS, NIGMS, ORIP

07/08/2021

Not Applicable

Standard dates apply

04/06/2022

R41/R42

PHS 2021-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Not Allowed)

PA-21-261

NIH

NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIBIB, NICHD, NIDA, NIDCD, NIEHS, NIGMS, NIMH, NIMHD, NINR

07/08/2021

Not Applicable

Standard dates apply

04/06/2022

R41/R42

PHS 2021-2 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42] Clinical Trial Required)

PA-21-260

NIH

NIDCD, NIAAA, NIEHS, NIDDK, NINR, NCI, NHLBI, NHGRI, NEI, NIMHD, NCCIH, NIBIB, NIA, NIMH, NICHD, NIDA, NIGMS

07/08/2021

Not Applicable

Standard dates apply

04/06/2022

R43/R44

PHS 2021-2 Omnibus Solicitation of the NIH and CDC for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44] Clinical Trial Required)

RFA-DK-21-021

NIDDK

NIAID

06/25/2021

January 17, 2022 and September 07, 2022

February 17, 2022 and October 7, 2022

10/08/2022

R43/R44

Support for Small Business Innovation Research (SBIR) to Develop New Methods and Technologies for Assessment of Risk and for Early Diagnosis and Prognosis of Type 1 Diabetes (R43/R44 Clinical Trial Not Allowed)

RFA-AG-22-007

NIA

06/10/2021

September 26, 2021

October 26, 2021

10/27/2021

R43/R44

NIA Research and Entrepreneurial Development Immersion (REDI): Entrepreneurial Small Business Transition Award (R43/R44 Clinical Trial Optional)

RFA-AG-22-014

NIA

06/10/2021

September 26, 2021

October 26, 2021

10/27/2021

R41/R42

NIA Research and Entrepreneurial Development Immersion (REDI): Entrepreneurial Small Business Transition Award (R41/R42 Clinical Trial Optional)

RFA-DK-21-012

NIDDK

05/19/2021

February 09, 2022 and September 7, 2022

March 9, 2022 and October 7, 2022

10/08/2022

R43/R44

Support for Small Business Innovation Research (SBIR) to Development and Testing of New Technologies and Bioengineering Solutions for the Advancement of Cell Replacement Therapies for Type 1 Diabetes (R43/R44 Clinical Trial Not Allowed)

RFA-ES-21-005

NIEHS

05/11/2021

June 30, 2021

July 30, 2021

07/31/2021

R43/R44

SBIR E-Learning for HAZMAT and Emergency Response (R43/R44 Clinical Trial Not Allowed)

RFA-DK-21-011

NIDDK

05/06/2021

February 9, 2022 and September 7, 2022

March 9, 2022 and October 7, 2022

10/08/2022

R43/R44

Support for Small Business Innovation Research (SBIR) to Develop New Technologies for Development and Integration of Novel Components for Open and Closed Loop Hormone Replacement Platforms for T1D Therapy (R43/R44 Clinical Trial Not Allowed)

PAR-21-224

NINDS

05/05/2021

Not Applicable

Standard dates apply *** Note new SBIR/STTR Standard Due Dates.

04/06/2024

U44

NeuroNEXT Small Business Innovation in Clinical Trials (U44 Clinical Trial Optional)

PAR-21-225

ORIP

04/30/2021

Not Applicable

Standard dates apply The first standard due date for this FOA isSeptember 6, 2021

09/06/2024

R43/R44

Novel Tools and Devices for Animal Research Facilities and to Support Care of Animal Models (R43/R44 Clinical Trial Not Allowed)

PAR-21-226

ORIP

04/30/2021

Not Applicable

Standard dates apply The first standard due date for this FOA is September 5, 2021

09/06/2024

R41/R42

Novel Tools and Devices for Animal Research Facilities and to Support Care of Animal Models (R41/R42 Clinical Trial Not Allowed)

RFA-NS-21-022

NINDS

04/28/2021

60 days prior to the receipt date.

July 1, 2021; October 20, 2021; February 18, 2022; June 20, 2022; October 18, 2022; February 21, 2023; June 19, 2023; October 18, 2023; February 20, 2024

02/21/2024

U44

Translational Neural Devices (U44 Clinical Trial Optional)

RFA-DA-22-001

NIDA

04/27/2021

July 13, 2021

August 13, 2021

08/14/2021

R43/R44

Mobile Health Solutions to rectify digital inequality in communities affected by drug addiction (R43/R44 Clinical Trial Optional)

PAR-21-233

NINDS

NIAAA, NIA, NCCIH, NICHD, NIBIB, NIMH, OBSSR, NIDCR, NIDA, NEI

04/23/2021

30 days prior to the application due date

August 10, 2021, February 9, 2022, August 9, 2022, February 9, 2023, August 9, 2023, February 9, 2024

04/06/2024

U44

Blueprint Neurotherapeutics Network (BPN): Biologic-based Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)

RFA-HD-22-018

NICHD

04/15/2021

30 days prior to application due date

July 29, 2021

07/30/2021

R43

Biomarker Research to Support Fertility Regulation Development by Small Business (R43 Clinical Trial Optional)

RFA-DA-22-019

NIDA

04/08/2021

Not Applicable

August 10, 2021 No late applications will be accepted for this Funding Opportunity Announcement.

08/11/2021

R43/R44

Leveraging Artificial Intelligence (AI) tools for Substance Use Disorders (SUD) drug discovery and development (R43/R44 - Clinical Trial Not Allowed)

RFA-DA-22-021

NIDA

04/08/2021

Not Applicable

August 10, 2021 No late applications will be accepted for this Funding Opportunity Announcement.

08/11/2021

R41/R42

Leveraging Artificial Intelligence (AI) tools for Substance Use Disorders (SUD) drug discovery and development (R41/R42 - Clinical Trial Not Allowed)

RFA-HD-22-010

NICHD

03/31/2021

30 days prior to the application due date

July 29, 2021

07/30/2021

R43/R44

Technologies to Advance Precision Medicine for Reproductive Health and Infertility (R43, R44 Clinical Trial Optional)

RFA-HG-21-008

NHGRI

03/30/2021

30 days prior to the application due date

June 25, 2021; March 1, 2022; February 1, 2023 All applications are due by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on the listed date(s). Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

02/02/2023

R43/R44

Transformative Nucleic Acid Sequencing Technology Innovation and Early Development (R43/R44)

RFA-HD-22-019

NICHD

03/29/2021

30 days prior to application receipt date

July 29, 2021

07/30/2021

R43

User-Based Design to Aid in Contraceptive Development by Small Business (R43 Clinical Trial Not Allowed)

RFA-CA-21-036

NCI

03/25/2021

July 6, 2021

August 6, 2021

08/07/2021

R44

SBIR Phase IIB Bridge Awards to Accelerate the Development of Cancer-Relevant Technologies Toward Commercialization (R44 Clinical Trial Optional)

PAR-21-114

NINDS

01/25/2021

30 days prior to the application due date

Standard dates apply The first standard due date for this FOA is April 5, 2021

01/06/2024

R44

NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Pre-Clinical Research (R44 Clinical Trial Not Allowed)

PAR-21-082

NIAID

01/14/2021

30 days prior to the application due date

May 14, 2021; September 13, 2021; January 14, 2022; May 13, 2022; September 13, 2022; January 13, 2023; May 13, 2023; September 14, 2023; January 13, 2024

01/14/2024

U44

NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44 Clinical Trial Required)

RFA-TR-21-010

NCATS

01/13/2021

March 13, 2021

April 13, 2021, September 13, 2021, January 12, 2022

01/13/2022

U44

Basket Clinical Trials of Drugs Targeting Shared Molecular Etiologies in Multiple Rare Diseases (U44 Clinical Trial Required)

PAR-21-059

NINDS

11/19/2020

30 days prior to the application due date.

March 15, 2021, June 22, 2021, February 22, 2022, June 22, 2022, February 22, 2023, and June 22, 2023

09/08/2023

U44

Clinical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional)

PAR-21-057

NINDS

11/19/2020

30 days prior to the application due date.

February 22, 2021, June 22, 2021, February 22, 2022 June 22, 2022, February 22, 2023, June 22, 2023

09/08/2023

U44

Analytical Validation of a Candidate Biomarker for Neurological or Neuromuscular Disorders (U44 Clinical Trial Optional)

RFA-MH-21-112

NIMH

11/13/2020

30 days prior to the application due date

?February 18, 2021; October 15, 2021, June 15, 2022

06/16/2022

R43/R44

Service-Ready Tools for Identification, Prevention, and Treatment of Individuals at Risk for Suicide (R43/R44 Clinical Trial Optional)

PAR-21-030

NIAMS

10/08/2020

December 5, 2020

Standard datesapply The first standard due date for this FOA is January 5, 2021.

09/06/2022

R43/R44

Late-Stage Translation of Biomedical and Behavioral Research Results in Arthritis and Musculoskeletal and Skin Diseases from Academic/Non-profit Lab to Marketplace (SBIR [R43/R44] Clinical Trial Not Allowed)

PAR-20-239

NIGMS

06/25/2020

Not Applicable

September 4, 2020; September 3, 2021; September 2, 2022

09/03/2022

R41/R42

Interactive Digital Media STEM Resources for Pre-College and Informal Science Education Audiences (STTR) (R41/R42 Clinical Trial Not Allowed)

PAR-20-244

NIGMS

06/25/2020

Not Applicable

September 4, 2020; September 3, 2021; September 2 , 2022

09/03/2022

R43/R44

Interactive Digital Media STEM Resources for Pre-College and Informal Science Education Audiences (SBIR) (R43/R44 Clinical Trial Not Allowed)

RFA-HG-20-016

NHGRI

NCATS

03/19/2020

30 days prior to the application due date

June 24, 2020; March 9, 2021; February 4, 2022 All applications are due by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity announcement are due on the listed date(s). Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

02/05/2022

R43/R44

Novel Synthetic Nucleic Acid Technology Development (R43/R44)( Clinical Trial not allowed)

PAR-20-111

NINDS

NCCIH, NIDCR, NIAAA, NICHD, NIDA, NIA, NEI, OBSSR, NIMH

03/03/2020

30 days prior to the application due date

August 11, 2020, February 9, 2021,August 10, 2021,February 9, 2022,August 9, 2022, February 9, 2023 by 5:00 PM local time of applicant organization.

05/08/2023

U44

Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44 Clinical Trial Optional)

PAR-20-109

NCATS

NINDS, NIA, NIGMS, NIAID

02/06/2020

30 days prior to the application due date

Standard dates apply The first standard due date for this FOA is April 5, 2020

01/06/2022

R41/R42

Non-Viral Technologies for in vivo Delivery of Genome Editors (R41/R42 Clinical Trial Not Allowed)

PAR-20-098

NCATS

NIA, NIGMS, NIAID, NINDS

02/06/2020

30 days prior to the application due date

Standard dates apply The first standard due date for this FOA is April 5, 2020

01/06/2022

R43/R44

Non-Viral Technologies for in vivo Delivery of Genome Editors (R43/R44 Clinical Trial Not Allowed)

PA-20-025

NIMH

NIEHS, NIGMS, NCATS, NIDCR, NIDA, NEI, NHGRI

01/07/2020

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization.

01/06/2023

R41/R42

Development of Highly Innovative Tools and Technology for Analysis of Single Cells (STTR) (R41/R42 Clinical Trial Not Allowed)

PA-20-047

NIMH

NCATS, NCI, NEI, NHGRI, NIDA, NIDCR, NIEHS, NIGMS

01/07/2020

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization.

01/06/2023

R43/R44

Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44 Clinical Trial Not Allowed)

RFA-NS-20-009

NINDS

NICHD, NIBIB, NIMH, NIDDK, NIAAA, NCCIH, ORIP, NIA, NIAMS, NHLBI, NIGMS, NCI, NIMHD, NCATS, NEI, NINR, NIDCR, NLM

10/04/2019

30 days prior to the application due date

January 8, 2020, April 7, 2020, September 9, 2020, January 6, 2021, April 6, 2021, September 8, 2021, January 6, 2022, April 6, 2022, and September 8, 2022

09/09/2022

R41/R42

HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Not Allowed)

RFA-NS-20-008

NINDS

NCCIH, NCI, NEI, NHLBI, NIA, NIAAA, NIAMS, NIBIB, NICHD, NIDDK, NIGMS, NIMH, NIMHD, NINR

10/04/2019

30 days prior to the application due date

January 8, 2020, April 7, 2020, September 9, 2020, January 6, 2021, April 6, 2021, September 8, 2021, January 6, 2022, April 6, 2022, and September 8, 2022

09/09/2022

R41/R42

HEAL Initiative: Development of Therapies and Technologies Directed at Enhanced Pain Management (R41/R42 Clinical Trial Required)

RFA-NS-20-010

NINDS

NCCIH, NCI, NEI, NHLBI, NIA, NIAAA, NIAMS, NIBIB, NICHD, NIDDK, NIGMS, NIMH, NIMHD, NINR

10/04/2019

30 days prior to the application due date

January 8, 2020, April 7, 2020, September 9, 2020, January 6, 2021, April 6, 2021, September 8, 2021, January 6, 2022, April 6, 2022, and September 8, 2022

09/09/2022

R43/R44

HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 - Clinical Trial Required)

RFA-NS-20-011

NINDS

NIAAA, NIA, NIAMS, NCCIH, NCI, NIDDK, NIGMS, NICHD, NIBIB, NIMHD, NLM, NIMH, NINR, NCATS, ORIP, NHLBI, NIDCR, NEI

10/04/2019

30 days prior to the application due date

January 8, 2020, April 7, 2020, September 9, 2020, January 6, 2021, April 6, 2021, September 8, 2021, January 6, 2022, April 6, 2022, and September 8, 2022

09/09/2022

R43/R44

HEAL INITIATIVE: Development of Therapies and Technologies Directed at Enhanced Pain Management (R43/R44 - Clinical Trial Not Allowed)

PAS-19-316

NIA

NINDS

07/18/2019

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization. All types of non-AIDS applications allowed for this funding opportunity are due on these dates. The first standard application due date for this FOA is September 5, 2019.

09/07/2022

R43/R44

Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R43/R44 Clinical Trial Optional)

PAS-19-317

NIA

NINDS

07/18/2019

Not Applicable

09/07/2022

R41/R42

Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R41/R42 Clinical Trial Optional)

RFA-DA-19-020

NIDA

NCATS

12/10/2018

30 days prior to the application due date

January 8, 2019, April 9, 2019, September 8, 2019, April 9, 2020, September 8, 2020, April 9, 2021, September 8, 2021, by 5:00 PM local time of applicant organization. No late applications will be accepted. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

09/09/2021

R41/R42

HEAL Initiative: Americas Startups and Small Businesses Build Technologies to Stop the Opioid Epidemic (R41/R42 - Clinical Trial Optional)

RFA-DA-19-019

NIDA

NCATS

12/10/2018

30 days prior to application due date

09/09/2021

R43/R44

HEAL Initiative: Americas Startups and Small Businesses Build Technologies to Stop the Opioid Epidemic (R43/R44 - Clinical Trial Optional)

PA-19-076

NIDCR

11/26/2018

Not Applicable

Standard dates apply

01/06/2022

R43/R44

Enabling Technologies to Accelerate Development of Oral Biodevices (R43/R44 Clinical Trial Not Allowed)

PA-19-075

NIDCR

11/26/2018

Not Applicable

Standard dates apply

01/06/2022

R41/R42

Enabling Technologies to Accelerate Development of Oral Biodevices (R41/R42 Clinical Trial Not Allowed)

PAR-19-061

NHGRI

11/08/2018

30 days prior to the application due date

Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

09/06/2021

R43/R44

Investigator Initiated Research in Computational Genomics and Data Science (R43/R44 Clinical Trial Not Allowed)

PA-19-043

NHGRI

10/31/2018

30 days prior to the application due date

09/06/2021

R43/R44

Novel Approaches for Relating Genetic Variation to Function and Disease (R43/R44 Clinical Trial Not Allowed)

PA-19-033

NIDCR

NCATS, NCI, NHLBI, NIMH, NLM

10/24/2018

Not Applicable

Standard dates apply by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.

09/06/2021

R41/R42

Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project (IDG) (R41/R42 Clinical Trial Not Allowed)

PA-19-034

NIDCR

NCATS, NCI, NHLBI, NIMH, NLM

10/24/2018

Not Applicable

Standard dates apply by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.

09/06/2021

R43/R44

Commercializing Understudied Proteins from the Illuminating the Druggable Genome Project (IDG) (R43/R44 Clinical Trial Not Allowed)

PA-19-022

NIDCR

10/09/2018

Not Applicable

Standard dates apply

09/06/2021

R43/R44

Advancing Imaging, Device Production, and Clinical Capabilities in Digital Dentistry (R43/R44 Clinical Trial Not Allowed)

PA-19-021

NIDCR

10/09/2018

Not Applicable

Standard dates apply

09/06/2021

R41/R42

Advancing Imaging, Device Production, and Clinical Capabilities in Digital Dentistry (R41/R42 Clinical Trial Not Allowed)

PA-18-927

NIMH

09/19/2018

Not Applicable

Standard dates apply , by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.

09/06/2021

R41/R42

Innovative Technologies for HIV Behavioral and Social Science Research (R41/R42 Clinical Trial Optional)

PA-18-928

NIMH

09/19/2018

Not Applicable

Standard dates apply , by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.

09/06/2021

R43/R44

Innovative Technologies for HIV Behavioral and Social Science Research (R43/R44 Clinical Trial Optional)

PA-18-709

NIMH

03/15/2018

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization.

09/06/2021

R41/R42

Novel Tools for Investigating Brain-derived GPCRs in Mental Health Research (R41/R42)-Clinical Trial Not Allowed

PA-18-708

NIMH

03/15/2018

30 days prior to the application due date

Standard dates apply , by 5:00 PM local time of applicant organization.

09/06/2021

R43/R44

Novel Tools for Investigating Brain-derived GPCRs in Mental Health Research (R43/R44 Clinical Trial Not Allowed)

PA-18-705

NINDS

NCI, NEI, NIA, NIAAA, NIDA, NIDCR, NINR

03/06/2018

Not Applicable

09/06/2021

R43/R44

SBIR Technology Transfer (R43/R44 Clinical Trial Not Allowed)

Targeted SBIR/STTR Funding Announcements

SBIR and STTR Omnibus Solicitations (Parent Announcements)

SBIR and STTR Funding Opportunities (63 Records - Sorted by Release Date)