Special Announcements for Small Business Research Opportunities

Targeted SBIR/STTR Funding Announcements

Receipt dates for the following Program Announcements (PAs) and Request for Applications (RFAs) may vary. See the NIH Guide for Grants and Contracts for all NIH RFA and PA announcements.

SBIR and STTR Omnibus Solicitations (Parent Announcements)

SBIR Omnibus (PA-17-302)
http://grants.nih.gov/grants/guide/pa-files/PA-17-302.html
Deadline: September 5, January 5*

STTR Omnibus (PA-17-303)
http://grants.nih.gov/grants/guide/pa-files/PA-17-303.html
Deadline: September 5, January 5*

*These Omnibus are being issued with limited due dates to accommodate the transition from FORMS-D to FORMS-E application packages. This FOA will be reissued for additional due date(s) on or after January 25, 2018.

HHS expects to re-issue these Omnibus after the January 5, 2018 due date.

Announcement Number	Issuing Organization	Other Participating Organizations	Release Date	Opening Date (SF424 Only)	Receipt Date(s)	Expiration Date	Activity Code(s)	Title
PA-18-119	NCCIH		01/05/2018	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization.	04/06/2019	R43/R44	Methods Development in Natural Products Chemistry (R43/R44 Clinical Trial Optional)
PA-18-122	NCCIH		01/05/2018	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization.	04/06/2019	R41/R42	Methods Development in Natural Products Chemistry (R41/R42 Clinical Trial Optional)
PAR-17-457	NINDS		08/14/2017	Not Applicable	February 13, 2018; July 18, 2018; February 13, 2019; July 18, 2019; February 13, 2020; and July 20, 2020 , by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	09/08/2020	U44	NINDS CREATE Bio Optimization Track for Biologics (U44)
RFA-DA-18-013	NIDA		07/12/2017	30 days prior to the application due date	December 5, 2017), by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	12/06/2017	R41/R42	Development of a Device to Objectively Measure Pain (R41/R42)
RFA-DA-18-012	NIDA		07/12/2017	30 days prior to the application due date	December 5, 2017), by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	12/06/2017	R43/R44	Development of a Device to Objectively Measure Pain (R43/R44)
RFA-ES-17-007	NIEHS		06/23/2017	September 4, 2017	October 4, 2017), by 5:00 PM local time of applicant organization.	10/05/2017	R44	Novel Assays for Screening the Effects of Chemical Toxicants on Cell Differentiation (SBIR R44)
PAR-17-300	NINDS		06/05/2017	Not applicable.	Standard dates apply , by 5:00 PM local time of applicant organization.	01/06/2018	U44	NeuroNEXT Small Business Innovation in Clinical Trials (U44)
PA-17-302	NIH	NCATS, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, ORIP, CBER, CFSAN, FDA	06/05/2017	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization. * Note new SBIR/STTR Standard Due Dates. This FOA is being issued with limited due dates to accommodate the transition from FORMS-D to FORMS-E application packages. This FOA will be reissued for additional due date(s) on or after January 25, 2018.** HHS expects to re-issue this Omnibus after the January 5, 2018 due date. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	01/06/2018	R43/R44	PHS 2017-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])
PA-17-303	NIH	NCATS, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, ORIP	06/05/2017	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization. * Note new SBIR/STTR Standard Due Dates. This FOA is being issued with limited due dates to accommodate the transition from FORMS-D to FORMS-E application packages. This FOA will be reissued for additional due date(s) on or after January 25, 2018.** HHS expects to re-issue this Omnibus after the January 5, 2018 due date. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	01/06/2018	R41/R42	PHS 2017-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])
PAR-17-275	NINDS		05/10/2017	Not Applicable	Standard dates apply by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date. This FOA is being issued with limited due dates to accommodate the transition from FORMS-D to FORMS-E application packages. This FOA will be reissued for additional due date(s) on or after January 25, 2018.	01/06/2018	U44	NIH StrokeNet Small Business Innovation Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (U44)
RFA-DA-18-007	NIDA		04/25/2017	July 24, 2017	August 23, 2017, by 5:00 PM local time of applicant organization.	08/24/2017	R41/R42	Nasal Delivery of CNS Therapeutics (R41/R42)
RFA-DA-18-006	NIDA		04/25/2017	July 24, 2017	August 23, 2017, by 5:00 PM local time of applicant organization.	08/24/2017	R43/R44	Nasal Delivery of CNS Therapeutics (R43/R44)
PAR-17-200	NICHD	NIDCD	03/29/2017	30 days prior to the application due date	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	01/06/2020	R41	Development of Appropriate Pediatric Formulations and Pediatric Drug Delivery Systems (R41)
PAR-17-199	NICHD	NIDCD	03/29/2017	30 days prior to the application due date	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	01/06/2020	R43	Development of Appropriate Pediatric Formulations and Pediatric Drug Delivery Systems (R43)
PAR-17-201	NINDS		03/09/2017	30 days prior to the application due date	August 9, 2017, Feb 6, 2018, Aug 9, 2018, Feb 9, 2019, August 9, 2019, Feb 11, 2020 , by 5:00 PM local time of applicant organization.	05/08/2020	U44	Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44)
PA-17-147	NIMH	NCATS, NCCIH, NCI, NEI, NHGRI, NIAMS, NIDA, NIDCR, NIDDK, NIEHS, NIGMS	02/01/2017	Not applicable	Standard dates apply , by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	01/06/2020	R43/R44	Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44)
PA-17-148	NIMH	NCATS, NCCIH, NCI, NHGRI, NIAMS, NIDCR, NIDDK, NIEHS	02/01/2017	30 days prior to the application due date	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	01/06/2020	R41/R42	Development of Highly Innovative Tools and Technology for Analysis of Single Cells (STTR) (R41/R42)
PA-17-130	NIDDK		01/24/2017	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization.	01/06/2020	R43/R44	Lead Optimization and Preclinical Development of Therapeutic Candidates for Diseases of Interest to the NIDDK (R43/R44)
PA-17-131	NIDDK		01/24/2017	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization.	01/06/2020	R41/R42	Lead Optimization and Preclinical Development of Therapeutic Candidates for Diseases of Interest to the NIDDK (R41/R42)
PAR-17-108	NIA		01/09/2017	30 days prior to the application due date	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	04/06/2020	R43/R44	Development of Socially-Assistive Robots (SARs) to Engage Persons with Alzheimer's Disease (AD) and AD-Related Dementias (ADRD), and their Caregivers (R43/R44)
PAR-17-107	NIA		01/09/2017	30 days prior to the application due date	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	04/06/2020	R41/R42	Development of Socially-Assistive Robots (SARs) to Engage Persons with Alzheimer's Disease (AD) and AD-Related Dementias (ADRD), and their Caregivers (R41/R42)
PAS-17-064	NIA		12/02/2016	Not Applicable	Standard dates apply , by 5:00 PM local time of applicant organization.	09/06/2019	R43/R44	Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R43/R44)
PAS-17-065	NIA		12/02/2016	30 days prior to the application due date	Standard dates apply, by 5:00 PM local time of applicant organization.	09/06/2019	R41/R42	Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R41/R42)
PAR-17-067	NIA		12/02/2016	30 days prior to the application due date	Standard dates apply, by 5:00 PM local time of applicant organization.	09/06/2019	R43/R44	Tools for Clinical Care and Management of Alzheimers Disease (AD) and its Comorbidities (R43/R44)
PAR-17-066	NIA		12/02/2016	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization.	09/06/2019	R41/R42	Tools for Clinical Care and Management of Alzheimers Disease (AD) and Its Comorbidities (R41/R42)
PAR-17-034	NIDDK		10/27/2016	30 days prior to the application due date	Standard dates apply, by 5:00 PM local time of applicant organization.	09/06/2019	R44	NIDDK Exploratory Clinical Trials for Small Business (R44)
PAR-17-036	NCATS	NIAID	10/27/2016	Not Applicable.	Standard dates apply by 5:00 PM local time of applicant organization.	09/06/2019	R41/R42	Platform Delivery Technologies for Nucleic Acid Therapeutics (R41/R42)
PAR-17-035	NCATS	NIAID, NIBIB	10/27/2016	Not Applicable.	Standard dates apply, by 5:00 PM local time of applicant organization.	09/06/2019	R43/R44	Platform Delivery Technologies for Nucleic Acid Therapeutics (R43/R44)
PAS-17-023	NCCIH		10/19/2016	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	01/06/2020	R41/R42	Development and/or Validation of Devices or Electronic Systems to Monitor or Enhance Mind and Body Interventions (R41/R42)
PAS-17-022	NCCIH		10/19/2016	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	01/06/2020	R43/R44	Development and/or Validation of Devices or Electronic Systems to Monitor or Enhance Mind and Body Interventions (R43/R44)
RFA-NS-17-007	NINDS	NCCIH, NEI, NIA, NIAAA, NIBIB, NICHD, NIDA, NIDCD, NIMH	09/29/2016	Not Applicable	December 21, 2016, and October 18, 2017, by 5:00 PM local time of applicant organization.	10/19/2017	U44	BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44)
PA-16-451	NIDDK		09/28/2016	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	01/06/2020	R41/R42	Kidney Precision Medicine Project - Technology Development and Validation (R41/R42)
PA-16-452	NIDDK		09/28/2016	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	01/06/2020	R43/R44	Kidney Precision Medicine Project - Technology Development and Validation (R43/R44)
PAR-16-410	NIAAA		08/17/2016	30 days before application due date	December 6, 2016; April, 4, 2017; December 6, 2017; April 4, 2018; December 6, 2018; April 4, 2019, by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.	04/05/2019	R43/R44	Wearable Alcohol Biosensors (R43/R44)
PAR-16-376	NIA		07/22/2016	30 days before application due date	Standard dates apply, by 5:00 PM local time of applicant organization.	09/06/2019	R43/R44	T2 Translational Research on Aging: Small Business Innovation Awards (R43/R44)
PAR-16-375	NIA		07/22/2016	30 days before application due date	Standard dates apply, by 5:00 PM local time of applicant organization.	09/06/2019	R43/R44	T1 Translational Research on Aging: Small Business Innovation Awards (R43/R44)
PA-16-341	NCCIH		06/23/2016	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization.	04/06/2019	R43/R44	Methods Development in Natural Products Chemistry (R43/R44)
PA-16-342	NCCIH		06/23/2016	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization.	04/06/2019	R41/R42	Methods Development in Natural Products Chemistry (R41/R42)
PAR-16-271	NIAID		05/18/2016	30 days prior to the application due date	September 13, 2016; January 13, 2017; May 12, 2017; September 13, 2017 January 12, 2018; May 14, 2018; September 13, 2018; January 14, 2019; May 13, 2019, by 5:00 PM local time of applicant organization.	05/14/2019	U44	NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44)
PA-16-208	NIAID		04/19/2016	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.	04/06/2019	R41/R42	The Use of mRNA for an HIV Envelope Vaccine (R41/R42)
PA-16-207	NIAID		04/19/2016	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.	04/06/2019	R43/R44	The Use of mRNA for an HIV Envelope Vaccine (R43/R44)
RFA-HL-17-012	NHLBI	NCATS	04/18/2016	30 days prior to the application due date	June 20, 2016; June 19, 2017; June 20, 2018, by 5:00 PM local time of applicant organization.	06/21/2018	R44	Small Market Awards: SBIR Phase IIB Competing Renewals for Heart, Lung, Blood, and Sleep Technologies with Small Commercial Markets (R44)
PA-16-186	NIGMS	NCATS, NCI, NHGRI, NIA, NIAID, NIBIB, NIDA, NIDCR, NINDS, ORIP, ORWH	04/15/2016	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.	04/06/2019	R43/R44	Tools for Cell Line Identification (R43/R44)
PA-16-184	NIAID		04/12/2016	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization.	04/06/2019	R43/R44	Strategies for the Improvement of HIV Envelope Protein Expression and Yield (R43/R44)
PA-16-182	NIAID		04/12/2016	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization.	04/06/2019	R41/R42	Strategies for the Improvement of HIV Envelope Protein Expression and Yield (R41/R42)
PAR-16-185	NIMH		04/12/2016	30 days prior to the application due date	Standard dates apply, by 5:00 PM local time of applicant organization.	04/06/2019	R43/R44	Products to Support Applied Research Towards Zero Suicide Healthcare Systems (R43/R44)
PA-16-180	ORIP		04/11/2016	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.	04/06/2019	R43/R44	Development and Commercialization of Technologies to Create, Characterize or Improve Animal Models of Human Disease (R43/R44)
PA-16-181	ORIP		04/11/2016	Not Applicable	Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.	04/06/2019	R41/R42	Development and Commercialization of Technologies to Create, Characterize or Improve Animal Models of Human Disease (R41/R42)
PA-16-158	NIGMS	NEI, NIDCR	03/30/2016	Not Applicable	Standard Due Dates	04/06/2019	R41/R42	New Technologies for the Glycosciences (R41/R42)
PA-16-157	NIGMS	NEI, NIDCR	03/30/2016	Not Applicable	Standard Due Dates	04/06/2019	R43/R44	New Technologies for the Glycosciences (R43/R44)
PAR-16-016	NHGRI		10/27/2015	30 days prior to application due	January 14, 2016; October 31, 2016; October 31, 2017, by 5:00 PM local time of applicant organization.	01/12/2018	R43/R44	Novel Genomic Technology Development (R43/R44)
PA-15-354	NINDS	NCATS, NCI, NEI, NIAAA, NIDA, NIDCR, NINR	09/21/2015	Not Applicable	Standard Due Dates	09/06/2018	R43/R44	SBIR Technology Transfer (R43/R44)
PA-15-336	NIDCR	NIBIB	08/20/2015	Not Applicable	Standard Due Dates	09/08/2018	R41/R42	Imaging Diagnostics of Dental Diseases and Conditions (Caries, Periodontal Disease, Cracked Teeth, and Pulp Vitality) (R41/R42)
PA-15-335	NIDCR	NIBIB	08/20/2015	Not Applicable	Standard Due Dates	09/08/2018	R43/R44	Imaging Diagnostics of Dental Diseases and Conditions (Caries, Periodontal Disease, Cracked Teeth, and Pulp Vitality) (R43/R44)
RFA-HG-15-033	NHGRI		08/17/2015	30 days prior to the application due date	October 27, 2015; July 14, 2016; June 15, 2017 , by 5:00 PM local time of applicant organization.	08/28/2017	R43/R44	Novel Nucleic Acid Sequencing Technology Development (R43/R44)
RFA-ES-15-016	NIEHS		07/09/2015	October 17 2015; October 14, 2016; October 13, 2017	November 17, 2015; November 14, 2016; November 13, 2017, by 5:00 PM local time of applicant organization.	11/14/2017	U44	NIEHS SBIR Phase IIB Awards for Validation and Commercialization of Approaches to Reduce Animal Use in Toxicology Testing (U44)
PAR-15-277	NINDS		06/15/2015	August 5, 2015	Standard Due Dates	04/06/2018	R44	NINDS Exploratory Clinical Trials for Small Business (R44)
PAR-15-278	NINDS		06/15/2015	August 5, 2015	Standard Due Dates	04/06/2018	R42	NINDS Exploratory Clinical Trials for Small Business (R42)
PAR-15-186	ORIP		04/16/2015	Not Applicable	Standard Due Dates	09/06/2018	R43/R44	Novel Tools and Devices for Animal Research Facilities and to Support the Care of Animal Models (R43/R44)
PAR-15-185	ORIP		04/16/2015	Not Applicable	Standard Due Dates	09/06/2018	R41/R42	Development of Novel Tools and Devices to Support the Care of Animal Models and Animal Care Research Facilities (R41/R42)
PAR-15-153	NIAAA		03/25/2015	30 days before application due date	June 11, 2015, December 9, 2015, May 10, 2016, December 9, 2016, May 9, 2017, December 11, 2017 , by 5:00 PM local time of applicant organization.	12/12/2017	UT2	Investigational New Drug (IND)-enabling Development of Medications to Treat Alcohol Use Disorder and Alcohol-related Disorders (UT2)
PAR-15-154	NIAAA		03/25/2015	30 days before application due date	12/11/2017	12/12/2017	U44	Investigational New Drug (IND)-enabling Development of Medications to Treat Alcohol Use Disorder and Alcohol-related Disorders (U44)
PAR-15-090	NIMH	NIA, NIAAA, NIDA, NIDCD, NINDS	01/16/2015	Not Applicable	Standard Due Dates	01/06/2018	R41/R42	BRAIN Initiative: Development, Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR) (R41/R42)
PAR-15-091	NIMH	NIA, NIAAA, NIBIB, NIDA, NIDCD, NINDS	01/16/2015	Not Applicable	Standard Due Dates	01/06/2018	R43/R44	BRAIN Initiative: Development, Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (SBIR) (R43/R44)
PA-15-086	ORIP	NICHD	01/12/2015	Not Applicable	Standard Due Dates	01/06/2018	R43/R44	Development of Novel and Emerging Technologies to Support Zebrafish Models for Biomedical Research (R43/R44)
PA-15-087	ORIP	NICHD	01/12/2015	Not Applicable	Standard Due Dates	01/06/2018	R41/R42	Development of Novel and Emerging Technologies to Support Zebrafish Models for Biomedical Research (R41/R42)
PA-15-076	NIDDK	NHLBI, NICHD	12/18/2014	Not Applicable	Standard Due Dates	01/08/2018	R41/R42	New Technologies for Viral Hepatitis STTR (R41/R42)
PA-15-077	NIDDK	NHLBI, NICHD	12/18/2014	Not Applicable	Standard Due Dates	01/08/2018	R43/R44	New Technologies for Viral Hepatitis SBIR (R43/R44)
PA-15-065	NIAID		12/10/2014	Not Applicable	Standard Due Dates	01/08/2018	R43/R44	Radiological/Nuclear Medical Countermeasure Product Development Program (R43/R44)
PA-15-052	ORIP	NIA	11/24/2014	Not Applicable	Standard Due Dates	01/08/2018	R43/R44	Lab to Marketplace: Tools for Biomedical and Behavioral Research (R43/R44)
PAR-14-289	NINDS		07/18/2014	Not Applicable	Application Due Date(s): October 21, 2014; February 11, 2015; August 11, 2015; February 11, 2016; August 11, 2016; February 8, 2017; July 18, 2017 AIDS Application Due Date(s): January 7, 2015, May 7, 2015, September 7, 2015, May 7, 2016, September 7, 2016, and May 7, 2017	09/08/2017	U44	NINDS CREATE Bio Development Track: Preclinical and Early-phase Clinical Development for Biotechnology Products and Biologics (U44)
PA-14-250	NIMH	NIDCD	06/05/2014		Standard Due Dates	01/06/2018	R43/R44	Lab to Marketplace: Tools for Brain and Behavioral Research (R43/R44)
PA-14-219	NIMH		05/13/2014	Not Applicable	Standard Due Dates	01/06/2018	R44	Renewal Awards of SBIR Phase IIB Grants for Brain and Behavior Tools (R44)
PAR-14-209	NINDS		05/07/2014	30 days before application due date	Standard Due Dates	09/06/2017	R44	NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Pre-Clinical Research (R44)
PAR-14-208	NINDS		05/07/2014	30 days before application due date	Standard Due Dates	09/06/2017	R44	NINDS Renewal Awards of SBIR Phase II Grants (Phase IIB) for Exploratory Clinical Trials and Clinical Research (R44)
PA-14-197	NIMH		04/30/2014	Not Applicable	Standard Due Dates	01/06/2018	R43/R44	Complex Technologies and Therapeutics Development for Mental Health Research and Practice (R43/R44)
PA-14-196	NIMH		04/30/2014	Not Applicable	Standard Due Dates	01/06/2018	R41/R42	Complex Technologies and Therapeutics Development for Mental Health Research and Practice (R41/R42)
PA-14-172	NIMH		04/04/2014	Not Applicable	Standard Due Dates	01/06/2018	R43/R44	Novel Tools for Investigating Brain-derived GPCRs in Mental Health Research (R43/R44)
PA-14-171	NIMH		04/04/2014	Not Applicable	Standard Due Dates	01/06/2018	R41/R42	Novel Tools for Investigating Brain-derived GPCRs in Mental Health Research (R41/R42)

Announcement
Number

Issuing
Organization

Other
Participating
Organizations

Release
Date

Opening Date
(SF424 Only)

Receipt
Date(s)

Expiration
Date

Activity
Code(s)

Title

PA-18-119

NCCIH

01/05/2018

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization.

04/06/2019

R43/R44

Methods Development in Natural Products Chemistry (R43/R44 Clinical Trial Optional)

PA-18-122

NCCIH

01/05/2018

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization.

04/06/2019

R41/R42

Methods Development in Natural Products Chemistry (R41/R42 Clinical Trial Optional)

PAR-17-457

NINDS

08/14/2017

Not Applicable

February 13, 2018; July 18, 2018; February 13, 2019; July 18, 2019; February 13, 2020; and July 20, 2020 , by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

09/08/2020

U44

NINDS CREATE Bio Optimization Track for Biologics (U44)

RFA-DA-18-013

NIDA

07/12/2017

30 days prior to the application due date

December 5, 2017), by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

12/06/2017

R41/R42

Development of a Device to Objectively Measure Pain (R41/R42)

RFA-DA-18-012

NIDA

07/12/2017

30 days prior to the application due date

12/06/2017

R43/R44

Development of a Device to Objectively Measure Pain (R43/R44)

RFA-ES-17-007

NIEHS

06/23/2017

September 4, 2017

October 4, 2017), by 5:00 PM local time of applicant organization.

10/05/2017

R44

Novel Assays for Screening the Effects of Chemical Toxicants on Cell Differentiation (SBIR R44)

PAR-17-300

NINDS

06/05/2017

Not applicable.

Standard dates apply , by 5:00 PM local time of applicant organization.

01/06/2018

U44

NeuroNEXT Small Business Innovation in Clinical Trials (U44)

PA-17-302

NIH

NCATS, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, ORIP, CBER, CFSAN, FDA

06/05/2017

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. ***This FOA is being issued with limited due dates to accommodate the transition from FORMS-D to FORMS-E application packages. This FOA will be reissued for additional due date(s) on or after January 25, 2018.*** HHS expects to re-issue this Omnibus after the January 5, 2018 due date. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

01/06/2018

R43/R44

PHS 2017-02 Omnibus Solicitation of the NIH, CDC, and FDA for Small Business Innovation Research Grant Applications (Parent SBIR [R43/R44])

PA-17-303

NIH

NCATS, NCCIH, NCI, NEI, NHGRI, NHLBI, NIA, NIAAA, NIAID, NIAMS, NIBIB, NICHD, NIDA, NIDCD, NIDCR, NIDDK, NIEHS, NIGMS, NIMH, NIMHD, NINDS, NINR, NLM, ORIP

06/05/2017

Not Applicable

01/06/2018

R41/R42

PHS 2017-02 Omnibus Solicitation of the NIH for Small Business Technology Transfer Grant Applications (Parent STTR [R41/R42])

PAR-17-275

NINDS

05/10/2017

Not Applicable

Standard dates apply by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date. This FOA is being issued with limited due dates to accommodate the transition from FORMS-D to FORMS-E application packages. This FOA will be reissued for additional due date(s) on or after January 25, 2018.

01/06/2018

U44

NIH StrokeNet Small Business Innovation Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (U44)

RFA-DA-18-007

NIDA

04/25/2017

July 24, 2017

August 23, 2017, by 5:00 PM local time of applicant organization.

08/24/2017

R41/R42

Nasal Delivery of CNS Therapeutics (R41/R42)

RFA-DA-18-006

NIDA

04/25/2017

July 24, 2017

August 23, 2017, by 5:00 PM local time of applicant organization.

08/24/2017

R43/R44

Nasal Delivery of CNS Therapeutics (R43/R44)

PAR-17-200

NICHD

NIDCD

03/29/2017

30 days prior to the application due date

Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

01/06/2020

R41

Development of Appropriate Pediatric Formulations and Pediatric Drug Delivery Systems (R41)

PAR-17-199

NICHD

NIDCD

03/29/2017

30 days prior to the application due date

01/06/2020

R43

Development of Appropriate Pediatric Formulations and Pediatric Drug Delivery Systems (R43)

PAR-17-201

NINDS

03/09/2017

30 days prior to the application due date

August 9, 2017, Feb 6, 2018, Aug 9, 2018, Feb 9, 2019, August 9, 2019, Feb 11, 2020 , by 5:00 PM local time of applicant organization.

05/08/2020

U44

Blueprint Neurotherapeutics Network (BPN): Small Molecule Drug Discovery and Development for Disorders of the Nervous System (U44)

PA-17-147

NIMH

NCATS, NCCIH, NCI, NEI, NHGRI, NIAMS, NIDA, NIDCR, NIDDK, NIEHS, NIGMS

02/01/2017

Not applicable

Standard dates apply , by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

01/06/2020

R43/R44

Development of Highly Innovative Tools and Technology for Analysis of Single Cells (SBIR) (R43/R44)

PA-17-148

NIMH

NCATS, NCCIH, NCI, NHGRI, NIAMS, NIDCR, NIDDK, NIEHS

02/01/2017

30 days prior to the application due date

01/06/2020

R41/R42

Development of Highly Innovative Tools and Technology for Analysis of Single Cells (STTR) (R41/R42)

PA-17-130

NIDDK

01/24/2017

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization.

01/06/2020

R43/R44

Lead Optimization and Preclinical Development of Therapeutic Candidates for Diseases of Interest to the NIDDK (R43/R44)

PA-17-131

NIDDK

01/24/2017

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization.

01/06/2020

R41/R42

Lead Optimization and Preclinical Development of Therapeutic Candidates for Diseases of Interest to the NIDDK (R41/R42)

PAR-17-108

NIA

01/09/2017

30 days prior to the application due date

04/06/2020

R43/R44

Development of Socially-Assistive Robots (SARs) to Engage Persons with Alzheimer's Disease (AD) and AD-Related Dementias (ADRD), and their Caregivers (R43/R44)

PAR-17-107

NIA

01/09/2017

30 days prior to the application due date

04/06/2020

R41/R42

Development of Socially-Assistive Robots (SARs) to Engage Persons with Alzheimer's Disease (AD) and AD-Related Dementias (ADRD), and their Caregivers (R41/R42)

PAS-17-064

NIA

12/02/2016

Not Applicable

Standard dates apply , by 5:00 PM local time of applicant organization.

09/06/2019

R43/R44

Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R43/R44)

PAS-17-065

NIA

12/02/2016

30 days prior to the application due date

Standard dates apply, by 5:00 PM local time of applicant organization.

09/06/2019

R41/R42

Advancing Research on Alzheimer's Disease (AD) and Alzheimer's-Disease-Related Dementias (ADRD) (R41/R42)

PAR-17-067

NIA

12/02/2016

30 days prior to the application due date

Standard dates apply, by 5:00 PM local time of applicant organization.

09/06/2019

R43/R44

Tools for Clinical Care and Management of Alzheimers Disease (AD) and its Comorbidities (R43/R44)

PAR-17-066

NIA

12/02/2016

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization.

09/06/2019

R41/R42

Tools for Clinical Care and Management of Alzheimers Disease (AD) and Its Comorbidities (R41/R42)

PAR-17-034

NIDDK

10/27/2016

30 days prior to the application due date

Standard dates apply, by 5:00 PM local time of applicant organization.

09/06/2019

R44

NIDDK Exploratory Clinical Trials for Small Business (R44)

PAR-17-036

NCATS

NIAID

10/27/2016

Not Applicable.

Standard dates apply by 5:00 PM local time of applicant organization.

09/06/2019

R41/R42

Platform Delivery Technologies for Nucleic Acid Therapeutics (R41/R42)

PAR-17-035

NCATS

NIAID, NIBIB

10/27/2016

Not Applicable.

Standard dates apply, by 5:00 PM local time of applicant organization.

09/06/2019

R43/R44

Platform Delivery Technologies for Nucleic Acid Therapeutics (R43/R44)

PAS-17-023

NCCIH

10/19/2016

Not Applicable

01/06/2020

R41/R42

Development and/or Validation of Devices or Electronic Systems to Monitor or Enhance Mind and Body Interventions (R41/R42)

PAS-17-022

NCCIH

10/19/2016

Not Applicable

01/06/2020

R43/R44

Development and/or Validation of Devices or Electronic Systems to Monitor or Enhance Mind and Body Interventions (R43/R44)

RFA-NS-17-007

NINDS

NCCIH, NEI, NIA, NIAAA, NIBIB, NICHD, NIDA, NIDCD, NIMH

09/29/2016

Not Applicable

December 21, 2016, and October 18, 2017, by 5:00 PM local time of applicant organization.

10/19/2017

U44

BRAIN Initiative: Next-Generation Invasive Devices for Recording and Modulation in the Human Central Nervous System (U44)

PA-16-451

NIDDK

09/28/2016

Not Applicable

01/06/2020

R41/R42

Kidney Precision Medicine Project - Technology Development and Validation (R41/R42)

PA-16-452

NIDDK

09/28/2016

Not Applicable

01/06/2020

R43/R44

Kidney Precision Medicine Project - Technology Development and Validation (R43/R44)

PAR-16-410

NIAAA

08/17/2016

30 days before application due date

December 6, 2016; April, 4, 2017; December 6, 2017; April 4, 2018; December 6, 2018; April 4, 2019, by 5:00 PM local time of applicant organization. Applicants are encouraged to apply early to allow adequate time to make any corrections to errors found in the application during the submission process by the due date.

04/05/2019

R43/R44

Wearable Alcohol Biosensors (R43/R44)

PAR-16-376

NIA

07/22/2016

30 days before application due date

Standard dates apply, by 5:00 PM local time of applicant organization.

09/06/2019

R43/R44

T2 Translational Research on Aging: Small Business Innovation Awards (R43/R44)

PAR-16-375

NIA

07/22/2016

30 days before application due date

Standard dates apply, by 5:00 PM local time of applicant organization.

09/06/2019

R43/R44

T1 Translational Research on Aging: Small Business Innovation Awards (R43/R44)

PA-16-341

NCCIH

06/23/2016

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization.

04/06/2019

R43/R44

Methods Development in Natural Products Chemistry (R43/R44)

PA-16-342

NCCIH

06/23/2016

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization.

04/06/2019

R41/R42

Methods Development in Natural Products Chemistry (R41/R42)

PAR-16-271

NIAID

05/18/2016

30 days prior to the application due date

September 13, 2016; January 13, 2017; May 12, 2017; September 13, 2017 January 12, 2018; May 14, 2018; September 13, 2018; January 14, 2019; May 13, 2019, by 5:00 PM local time of applicant organization.

05/14/2019

U44

NIAID SBIR Phase II Clinical Trial Implementation Cooperative Agreement (U44)

PA-16-208

NIAID

04/19/2016

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.

04/06/2019

R41/R42

The Use of mRNA for an HIV Envelope Vaccine (R41/R42)

PA-16-207

NIAID

04/19/2016

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.

04/06/2019

R43/R44

The Use of mRNA for an HIV Envelope Vaccine (R43/R44)

RFA-HL-17-012

NHLBI

NCATS

04/18/2016

30 days prior to the application due date

June 20, 2016; June 19, 2017; June 20, 2018, by 5:00 PM local time of applicant organization.

06/21/2018

R44

Small Market Awards: SBIR Phase IIB Competing Renewals for Heart, Lung, Blood, and Sleep Technologies with Small Commercial Markets (R44)

PA-16-186

NIGMS

NCATS, NCI, NHGRI, NIA, NIAID, NIBIB, NIDA, NIDCR, NINDS, ORIP, ORWH

04/15/2016

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.

04/06/2019

R43/R44

Tools for Cell Line Identification (R43/R44)

PA-16-184

NIAID

04/12/2016

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization.

04/06/2019

R43/R44

Strategies for the Improvement of HIV Envelope Protein Expression and Yield (R43/R44)

PA-16-182

NIAID

04/12/2016

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization.

04/06/2019

R41/R42

Strategies for the Improvement of HIV Envelope Protein Expression and Yield (R41/R42)

PAR-16-185

NIMH

04/12/2016

30 days prior to the application due date

Standard dates apply, by 5:00 PM local time of applicant organization.

04/06/2019

R43/R44

Products to Support Applied Research Towards Zero Suicide Healthcare Systems (R43/R44)

PA-16-180

ORIP

04/11/2016

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.

04/06/2019

R43/R44

Development and Commercialization of Technologies to Create, Characterize or Improve Animal Models of Human Disease (R43/R44)

PA-16-181

ORIP

04/11/2016

Not Applicable

Standard dates apply, by 5:00 PM local time of applicant organization. *** Note new SBIR/STTR Standard Due Dates.

04/06/2019

R41/R42

Development and Commercialization of Technologies to Create, Characterize or Improve Animal Models of Human Disease (R41/R42)

PA-16-158

NIGMS

NEI, NIDCR

03/30/2016

Not Applicable

Standard Due Dates

04/06/2019

R41/R42

New Technologies for the Glycosciences (R41/R42)

PA-16-157

NIGMS

NEI, NIDCR

03/30/2016

Not Applicable

Standard Due Dates

04/06/2019

R43/R44

New Technologies for the Glycosciences (R43/R44)

PAR-16-016

NHGRI

10/27/2015

30 days prior to application due

January 14, 2016; October 31, 2016; October 31, 2017, by 5:00 PM local time of applicant organization.

01/12/2018

R43/R44

Novel Genomic Technology Development (R43/R44)

PA-15-354

NINDS

NCATS, NCI, NEI, NIAAA, NIDA, NIDCR, NINR

09/21/2015

Not Applicable

Standard Due Dates

09/06/2018

R43/R44

SBIR Technology Transfer (R43/R44)

PA-15-336

NIDCR

NIBIB

08/20/2015

Not Applicable

Standard Due Dates

09/08/2018

R41/R42

Imaging Diagnostics of Dental Diseases and Conditions (Caries, Periodontal Disease, Cracked Teeth, and Pulp Vitality) (R41/R42)

PA-15-335

NIDCR

NIBIB

08/20/2015

Not Applicable

Standard Due Dates

09/08/2018

R43/R44

Imaging Diagnostics of Dental Diseases and Conditions (Caries, Periodontal Disease, Cracked Teeth, and Pulp Vitality) (R43/R44)

RFA-HG-15-033

NHGRI

08/17/2015

30 days prior to the application due date

October 27, 2015; July 14, 2016; June 15, 2017 , by 5:00 PM local time of applicant organization.

08/28/2017

R43/R44

Novel Nucleic Acid Sequencing Technology Development (R43/R44)

RFA-ES-15-016

NIEHS

07/09/2015

October 17 2015; October 14, 2016; October 13, 2017

November 17, 2015; November 14, 2016; November 13, 2017, by 5:00 PM local time of applicant organization.

11/14/2017

U44

NIEHS SBIR Phase IIB Awards for Validation and Commercialization of Approaches to Reduce Animal Use in Toxicology Testing (U44)

PAR-15-277

NINDS

06/15/2015

August 5, 2015

Standard Due Dates

04/06/2018

R44

NINDS Exploratory Clinical Trials for Small Business (R44)

PAR-15-278

NINDS

06/15/2015

August 5, 2015

Standard Due Dates

04/06/2018

R42

NINDS Exploratory Clinical Trials for Small Business (R42)

PAR-15-186

ORIP

04/16/2015

Not Applicable

Standard Due Dates

09/06/2018

R43/R44

Novel Tools and Devices for Animal Research Facilities and to Support the Care of Animal Models (R43/R44)

PAR-15-185

ORIP

04/16/2015

Not Applicable

Standard Due Dates

09/06/2018

R41/R42

Development of Novel Tools and Devices to Support the Care of Animal Models and Animal Care Research Facilities (R41/R42)

PAR-15-153

NIAAA

03/25/2015

30 days before application due date

June 11, 2015, December 9, 2015, May 10, 2016, December 9, 2016, May 9, 2017, December 11, 2017 , by 5:00 PM local time of applicant organization.

12/12/2017

UT2

Investigational New Drug (IND)-enabling Development of Medications to Treat Alcohol Use Disorder and Alcohol-related Disorders (UT2)

PAR-15-154

NIAAA

03/25/2015

30 days before application due date

12/11/2017

12/12/2017

U44

Investigational New Drug (IND)-enabling Development of Medications to Treat Alcohol Use Disorder and Alcohol-related Disorders (U44)

PAR-15-090

NIMH

NIA, NIAAA, NIDA, NIDCD, NINDS

01/16/2015

Not Applicable

Standard Due Dates

01/06/2018

R41/R42

BRAIN Initiative: Development, Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (STTR) (R41/R42)

PAR-15-091

NIMH

NIA, NIAAA, NIBIB, NIDA, NIDCD, NINDS

01/16/2015

Not Applicable

Standard Due Dates

01/06/2018

R43/R44

BRAIN Initiative: Development, Optimization, and Validation of Novel Tools and Technologies for Neuroscience Research (SBIR) (R43/R44)

PA-15-086

ORIP

NICHD

01/12/2015

Not Applicable

Standard Due Dates

01/06/2018

R43/R44

Development of Novel and Emerging Technologies to Support Zebrafish Models for Biomedical Research (R43/R44)

PA-15-087

ORIP

NICHD

01/12/2015

Not Applicable

Standard Due Dates

01/06/2018

R41/R42

Development of Novel and Emerging Technologies to Support Zebrafish Models for Biomedical Research (R41/R42)

PA-15-076

NIDDK

NHLBI, NICHD

12/18/2014

Not Applicable

Standard Due Dates

01/08/2018

R41/R42

New Technologies for Viral Hepatitis STTR (R41/R42)

PA-15-077

NIDDK

NHLBI, NICHD

12/18/2014

Not Applicable

Standard Due Dates

01/08/2018

R43/R44

New Technologies for Viral Hepatitis SBIR (R43/R44)

PA-15-065

NIAID

12/10/2014

Not Applicable

Standard Due Dates

01/08/2018

R43/R44

Radiological/Nuclear Medical Countermeasure Product Development Program (R43/R44)

PA-15-052

ORIP

NIA

11/24/2014

Not Applicable

Standard Due Dates

01/08/2018

R43/R44

Lab to Marketplace: Tools for Biomedical and Behavioral Research (R43/R44)

PAR-14-289

NINDS

07/18/2014

Not Applicable

Application Due Date(s): October 21, 2014; February 11, 2015; August 11, 2015; February 11, 2016; August 11, 2016; February 8, 2017; July 18, 2017 AIDS Application Due Date(s): January 7, 2015, May 7, 2015, September 7, 2015, May 7, 2016, September 7, 2016, and May 7, 2017

09/08/2017

U44

NINDS CREATE Bio Development Track: Preclinical and Early-phase Clinical Development for Biotechnology Products and Biologics (U44)

PA-14-250

NIMH

NIDCD

06/05/2014

Standard Due Dates

01/06/2018

R43/R44

Lab to Marketplace: Tools for Brain and Behavioral Research (R43/R44)

PA-14-219