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Small Business Funding Opportunities


Most of the applications that the NIDDK funds are investigator-initiated and are submitted in response to the Omnibus/Parent SBIR & STTR Funding Opportunity Announcements (FOAs). These funding opportunities and others can be found here. 

At the same time, the NIDDK has a number of targeted FOAs crafted to support institute priorities or initiatives. The NIDDK permits several application types (Phase I, Phase II, Direct Phase II - SBIR only, Phase IIB, and Fast-Track). Both appropriateness of application type for your planned efforts and the responsiveness of your proposed project to the funding opportunity should go into your selection of a FOA. Furthermore, the size and scope of some application types (e.g., Phase IIB) vary with Institute or Center (IC). More information regarding the NIDDK’s policies on application types can be found in the Program Descriptions and Research Topics document that accompanies the Omnibus FOAs.

For a list of NIDDK SBIR & STTR FOAs, click here. This table on the NIDDK website can be used to view non-SBIR/STTR FOAs as well.

Selecting a Funding Opportunity

While CSR will ensure your application is routed to the appropriate IC, you must identify a target funding opportunity. Before crafting your proposal, evaluate all of your options, and talk to the Program Director listed in the FOA about whether your research will be considered responsive.

For a quick primer on the FOA naming and numbering system, click here. The prefix will tell you something about whether or not there are set-aside funds or a special review group for the funding opportunity.

Be sure to check out the list of targeted funding announcements maintained on the NIH SBIR website. Even if your prior research has been supported by the NIDDK, your technology may be relevant to the efforts and missions of many ICs. Many of our SBIR & STTR grantees also have awards from other ICs to support alternative applications of their technology (please bear in mind, there can be no overlap between awards). Lastly, just because you are a small business does not mean you need to limit yourself to SBIR & STTR mechanisms. You may be eligible to compete for other types of awards and should find the right mechanism for the stage, breadth, and timeline of your proposed research or research & development. Find grants and cooperative agreements supported by other funding mechanisms in the NIDDK Current Funding Opportunities table.

Clinical Trials

For clinical trials, NIDDK currently only accepts SBIR (not STTR) Phase II, Direct Phase II, Phase IIB, and Fast-Track applications. These applications can be accepeted through the relevant Omnibus/Parent FOA. If you are proposing human subjects research, please review the NIH Clinical Trial Definition and Case Studies to ensure your application is submitted to an apporpriate funding opportunity. Additional details on NIDDK's clinical trial funding opportunities can be found in the Program Descriptions and Research Topics document that accompanies the Omnibus/Parent FOAs.


Standard receipts dates were changed December 17, 2014 in order to accommodate the needs of the small business community--shortening the period between application and award. Receipt dates are now January 5 (starting 2016), April 5, and September 5. Effective September 5, 2015 HHS SBIR/STTR grant applications will no longer be accepted on AIDS and AIDS-related Due Dates (May 7, September 7, and January 7). For a full review schedule, click here.

For additional details of the application process, see the SBIR/STTR Application Process Infographic created by the NIH Office of Extramural Research:



The NIH SBIR website has outlined the critical differences between the SBIR & STTR programs here, and the NIDDK maintains pages describing R41/R42 (STTR) and R43/R44 (SBIR) mechanisms. The differences principally involve the primary employment of the Principal Investigator and the commitment levels of the Small Business Concern and the Non-Profit Research Partners. It is also worth noting that a larger portion of the budget is set-aside for the SBIR program and that some funding opportunities are available to only one of the programs.


Translational Pipeline

The NIDDK supports projects all the way through the development pipeline, from target identification through clinical trials. In addition to the Omnibus/Parent SBIR/STTR FOAs, which may be used to support any segment of this pipeline, we participate in a series of FOAs to encourage translation of basic discoveries into novel therapeutics. Find these funding opportunities and related resources mapped to critical segments of the therapeutic discovery and development pipeline at NIDDK’s website.